Confirmation of that interpretation in an article Here :- ” the accompanying (Lancet) editorial points out, it is somewhat surprising that none of the genes identified are linked with skin pigmentation”
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A systematic review of the association between common single nucleotide polymorphisms and 25-hydroxyvitamin D concentrations
“We speculate that recently identified U-shaped relationships between 25OHD concentrations and disease outcomes (i.e. increased risk at both high and low concentrations) may reflect a mixture of genotype-defined subgroups.”

‘Genetics to Blame for Vitamin D Deficiency?’
“Researchers conducted a genome-wide association study (Common genetic determinants of vitamin D insufficiency: a genome-wide association study) that involved almost 34,000 people of European descent from 15 different studies. They used radioimmunoassay and mass spectrometry to determine vitamin D concentrations and found that variants at three genetic sites, or “loci,” were significantly associated with vitamin D concentrations. The presence of harmful alleles at three “loci” more than doubled the risk of Vitamin D insufficiency.”

Maybe non-whites are the ones who benefit from doubling their vitamin D levels ? Nope – Vitamin D, Adiposity, and Calcified Atherosclerotic Plaque in African-Americans “positive associations exist between 25-hydroxyvitamin D and aorta and carotid artery CP in African-Americans”

Many people are naturally low in vitamin D, forcing vitamin D levels up by taking supplements can only do harm. If you think you can improve yor health by conforming to the advice of Holick or – God forbid – that of Hollis, Cannel & Co at the vitamin D ‘Council’ who recommend (>50ng/ml) then you are in for an unpleasant surprise.

Vitamin D and homeostasis

Mad dogs and ….

It is impossible because body fat absorbs vitamin D and makes it unavailable. Vitamin D is fat soluble and fat is where it gets stuck.

Sensible sun exposure with no sunscreen and never burning is a reasonable approach. In winter the experts reccomend 75iu/kg/d.
That is 75iu of vitamin D per kilogram of body weight, daily.