Do Wrinkle Creams Really Work?

Many of our readers who are starting to show their age have written in and asked, “Do wrinkle creams really work?” Every brand of wrinkle cream claims to have some positive effect when it comes to rejuvenating your skin, but is it possible that the manufacturers would actually lie? After all, we’re talking about products which claim to have the same effects on wrinkles as expensive injections of Restalyne, Juva Derm, or Botox.

Top Wrinkle Creams

Before we investigate the question, “Do wrinkle creams really work,” let’s take a look at some of the top wrinkle creams on the market. We’ll explore their ingredients, price, and level of customer satisfaction.

  • Prototype #37-C (Elldia Laboratories) – Peptides are believed to be an important component in wrinkle creams, but most only contain a 2 to 5 percent concentration. This anti-wrinkle cream contains a 99 percent concentration of peptides. Over the last several years, this product has been the highest-rated wrinkle cream by both consumers and experts. It costs $149.99 and comes with a money-back guarantee.
  • Dermavexin (Dermavexin Laboratories) – This wrinkle cream uses “stem cell” technology to stimulate the regeneration of skin cells. The manufacturer claims that users will notice results within the first week of use. 90 % of your wrinkles are supposed to disappear within 4 to 6 months of use. This anti-wrinkle product can be purchased online for $125.
  • Regenerist (Olay) – The key ingredient in this anti-wrinkle cream is palmitoyl pentapeptide. The cost is $18 for 1.7 ounces.
  • Principal Secret Reclaim Anti-Aging Night Cream – The key ingredient in this product is argireline. The price is $40 for one ounce.
  • Strivectin-SD (Klein Becker) – The main ingredient in this best-selling wrinkle cream is oligopeptide palmitoyl. The price for 6 ounces is $135.
  • Prevara (ENR) – This anti-wrinkle product combines moisturizing products and wrinkle treatments. It can be purchased only for a price of $29.99.
  • Renuvie (Orovo) – Contains a mixture of peptides, natural oils, moisturizers, and antioxidants. The manufacturer claims that this product will brighten the skin, soften deep wrinkles and eliminate crow’s feet. For $70, you receive the wrinkle cream plus a kit with day and night anti-aging cream.
  • Strivectin SD (Klein-Becker) – While trying to find a cure for stretch marks, this product was inadvertently created. It uses a blend of skin moisturizers, elesticizers and skin forming agents to eliminate wrinkles and soften the skin. Available for $135, it includes the following ingredients: deionized water, C-12-15 Alkyl Benzoate, sesame oil, caprylic/capric triglyceride, sweet almond oil, cetearyl olivate, sorbitan olivate, striadril complex, glycerin, PPG-12/SMDI copolymer, glyceryl stearate, PEG 100 stearate, cocoa butter, stearic acid, shea butter, tocopheryl acetate, mango butter, peppermint oil, methylparaben, xanthan gum, propylparaben, triethanolamine, butylene glycol, disodium EDTA, retinyl palmitate, and tetrahexyldecyl ascorbate.
  • Wrinkle Control Intensely Lifting Eye Gel with Revolox – The key element for this anti-wrinkle cure is acetyl hexapeptide-3. For 0.5 ounces, you‘ll have to spend $19.99.
  • Wrinkle Relax by Doctor’s Dermatologic Formula – Costs $75 for 0.5 ounces and contains acetyl hexapeptide-3 and palimtoyl pentatpeptide-3.

Wrikle Cream Skepticism


So do wrinkle creams really work? Most dermatologists are skeptical; in fact, one pointed out that if wrinkle creams worked as advertised, they would be drugs and not cosmetics.

Many wrinkle creams focus on pentapeptides (peptides for short), groups of amino acids which act as chemical messengers in the human body. Researchers say that peptides help skin to heal and also to produce more collagen (which is what supports our skin and gives it a youthful appearance). Some anti-wrinkle products also contain herbs and vitamins which help combat the effects of aging.

But despite claims by many wrinkle cream producers, there is a lack of published medical studies on the topic. Until that situation changes, most in the medical community will continue to remain skeptical about the benefits of wrinkle creams.

The bottom line is this: using wrinkle creams may help to eliminate tiny wrinkles and prevent some new ones from forming, but it will not take away large wrinkles or completely block the effects of aging. If you want effective and long-lasting results on more noticeable wrinkles, you may need to look into Botox and wrinkle-filling injections.